Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine + N-terminal-PPKRIA-[RCC1] | Homo sapiens | - |
3 S-adenosyl-L-homocysteine + N-terminal-trimethyl-PPKRIA-[RCC1] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BV86 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + CPKRIA | mono- and dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + FPKRIA | dimethylation and low level trimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + HPKRIA | dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + IPKRIA | mono- and dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + KPKRIA | dimethylation and low level trimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + LPKRIA | dimethylation and low level trimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + MPKRIA | dimethylation and low level trimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + NPKRIA | dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + PPKRIA | dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + QPKRIA | dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + RPKRIA | dimethylation and low level trimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + TPKRIA | mono- and dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + VPKRIA | mono- and dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + WPKRIA | mono- and dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
2 S-adenosyl-L-methionine + YPKRIA | dimethylation by NTMT1 | Homo sapiens | 2 S-adenosyl-L-homocysteine + ? | - |
? | |
3 S-adenosyl-L-methionine + APKRIA | trimethylation by NTMT1 | Homo sapiens | 3 S-adenosyl-L-homocysteine + ? | - |
? | |
3 S-adenosyl-L-methionine + GPKRIA | trimethylation by NTMT1 | Homo sapiens | 3 S-adenosyl-L-homocysteine + ? | - |
? | |
3 S-adenosyl-L-methionine + N-terminal-PPKRIA-[RCC1] | - |
Homo sapiens | 3 S-adenosyl-L-homocysteine + N-terminal-trimethyl-PPKRIA-[RCC1] | - |
? | |
3 S-adenosyl-L-methionine + N-terminal-[RCC1] | - |
Homo sapiens | 3 S-adenosyl-L-homocysteine + ? | - |
? | |
3 S-adenosyl-L-methionine + SPKRIA | trimethylation by NTMT1 | Homo sapiens | 3 S-adenosyl-L-homocysteine + ? | - |
? | |
additional information | NTMT1 is a tri-methyltransferase | Homo sapiens | ? | - |
- |
|
S-adenosyl-L-methionine + DPKRIA | monomethylation by NTMT1 | Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + EPKRIA | monomethylation by NTMT1 | Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-N-terminal methyltransferase 1 | - |
Homo sapiens |
N-terminal methyltransferase | - |
Homo sapiens |
NTMT1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | dependent on | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | structural comparison of isozymes NTMT1 and NTMT2 (EC 2.1.1.299), overview. NTMT1 and NTMT2 employ a similar substrate recognition mode | Homo sapiens |
malfunction | knockdown of NTMT1 results in hypersensitivity of breast cancer cell lines to doublestranded DNA breaks (DSBs) and increased proliferation of estrogen receptor positive breast cancer cells MCF-7 and LCC9 | Homo sapiens |
additional information | substrate and ligand binding structures of NTMT1 and NTMT2 (EC 2.1.1.299), overview | Homo sapiens |
physiological function | protein lysine/arginine methylation, the addition of a methyl group at the free alpha-N-termini of proteins represents a unique mode of post-translational modification. NTMT1 is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase. During the enzymatic reaction, NTMT1 transfers a methyl group from SAM to the alpha-amino group of the protein substrates, resulting in the production of S-adenosyl-L-homocysteine (SAH) and alpha-N-methylated proteins. NTMT1 recognizes proteins bearing an N-terminal X-P-K/R consensus sequence, including RCC1, RB1, DDB2, CENP-A/B, PARP3, etc. | Homo sapiens |