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Literature summary for 2.1.1.247 extracted from

  • Harms, U.; Thauer, R.
    Methylcobalamin:coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri: Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli (1996), Eur. J. Biochem., 235, 653-659.
    View publication on PubMed
Search for more literature for 2.1.1.247

Cloned(Commentary)

Cloned (Comment) Organism
gene mtbA, DNA and amino acid sequence determination and analysis, gene mtbA is monocislronically transcribed Methanosarcina barkeri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M Methanosarcina barkeri
-
 methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M Methanosarcina barkeri DSM 804
-
 methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M Methanosarcina barkeri
-
 methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M Methanosarcina barkeri DSM 804
-
 methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M Methanosarcina barkeri
-
 methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M Methanosarcina barkeri DSM 804
-
 methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina barkeri
-
 Fusaro, gene mtbA
-
Methanosarcina barkeri DSM 804
-
 Fusaro, gene mtbA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M
-
 Methanosarcina barkeri methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M
-
 Methanosarcina barkeri DSM 804 methyl-CoM + a [Co(I) dimethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M
-
 Methanosarcina barkeri methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) monomethylamine-specific corrinoid protein] + coenzyme M
-
 Methanosarcina barkeri DSM 804 methyl-CoM + a [Co(I) monomethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M
-
 Methanosarcina barkeri methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]
-
 ?
a [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M
-
 Methanosarcina barkeri DSM 804 methyl-CoM + a [Co(I) trimethylamine-specific corrinoid protein]
-
 ?

Synonyms

Synonyms Comment Organism
methylcobamide:coenzyme M methyltransferase
-
 Methanosarcina barkeri
mtbA
-
 Methanosarcina barkeri

Expression

Organism Comment Expression
Methanosarcina barkeri mtbA is induced by growth on trimethylamine up