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Literature summary for 2.1.1.249 extracted from
- Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases (2004), Curr. Opin. Chem. Biol., 8, 484-491.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene mtbB, DNA and amino acid sequence determination and analysis, UAG is not the stop codon in the encoding gene, no UAG modification | Methanosarcina barkeri |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
1 * 50000 | Methanosarcina barkeri |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] | Methanosarcina barkeri | - |
a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanosarcina barkeri | O30642 | gene mtbB | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dimethylamine + a [Co(I) dimethylamine-specific corrinoid protein] | - |
Methanosarcina barkeri | a [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 50000 | Methanosarcina barkeri |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DMA methyltransferase | - |
Methanosarcina barkeri |
| MtbB | - |
Methanosarcina barkeri |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | biochemistry of methane formation by Methanosarcina species from monomethylamine, dimethylamine, and trimethylamine: methanogenesis from these substrates is initiated by three methyltransferases that specifically methylate their cognate corrinoid proteins with one of these methylamines, cf. EC 2.1.1.250 and EC 2.1.1.248, overview | Methanosarcina barkeri |
| physiological function | the enzyme is involved in the corrinoid-dependent demethylation of methylamines, which are used for coenzyme M methylation | Methanosarcina barkeri |
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Release 2023.1 (January 2023)
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