Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.28 extracted from

  • Connett, R.J.; Kirshner, N.
    Purification and properties of bovine phenylethanolamine N-methyltransferase (1970), J. Biol. Chem., 245, 329-334.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
p-hydroxymercuribenzoate 0.00001 mM, 75% loss of activity Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
sucrose density gradient centrifugation Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine random binding mechanism with a kinetically preferred order of binding where S-adenosyl-L-methionine is the preferred first substrate Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
normetanephrine + S-adenosyl-L-methionine
-
Bos taurus metanephrine + S-adenosyl-L-homocysteine
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
presence of 2.5 mM normetanephrine has no effect on the heat denaturation, 1 mM S-adenosyl-L-methionine decreases the rate of inactivation Bos taurus
39
-
stable for at least 50 min Bos taurus
45
-
activity is rapidly destroyed Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.9
-
Tris or borate buffer Bos taurus