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Literature summary for 2.1.1.28 extracted from

  • Gearhart, D.A.; Neafsey, E.J.; Collins, M.A.
    Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease (2002), Neurochem. Int., 40, 611-620.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
LY134046 selective inhibitor, IC50: 0.0019 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
9-methylnorharman + S-adenosyl-L-methionine Homo sapiens PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ ? + S-adenosyl-L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9-methylnorharman + S-adenosyl-L-methionine 2N-methylation Homo sapiens ? + S-adenosyl-L-homocysteine
-
 ?
9-methylnorharman + S-adenosyl-L-methionine PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ Homo sapiens ? + S-adenosyl-L-homocysteine
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0019
-
 selective inhibitor, IC50: 0.0019 mM Homo sapiens LY134046