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Literature summary for 2.1.1.28 extracted from

  • Drinkwater, N.; Vu, H.; Lovell, K.M.; Criscione, K.R.; Collins, B.M.; Prisinzano, T.E.; Poulsen, S.A.; McLeish, M.J.; Grunewald, G.L.; Martin, J.L.
    Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors (2010), Biochem. J., 431, 51-61.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
C-terminally His-tagged hPNMT is expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-aminoisoquinoline Kd: 14 microM Homo sapiens
2-amino-1-methylbenzimidazole Kd: 4.6 microM Homo sapiens
2-amino-4(7)-hydroxy-benzimidazole Kd: 20 microM Homo sapiens
2-amino-5(6)-chloro-7(4)-hydroxy-benzimidazole Kd: 14 microM Homo sapiens
2-amino-5(6)-chloro-benzimidazole Kd: 1.8 microM Homo sapiens
2-amino-5(6)-fluoro-benzimidazole Kd: 7.2 microM Homo sapiens
2-aminobenzimidazole Kd: 6.3 microM Homo sapiens
4-bromo-1H-imidazole Kd: 170 microM Homo sapiens
4-quinolinol Kd: 690 microM Homo sapiens
5-chlorobenzimidazole Kd: 97 microM Homo sapiens
6-Aminoquinoline Kd: 380 microM Homo sapiens
6-Chloropurine Kd: 140 microM Homo sapiens
adenine Kd: 180 microM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
hPNMT
-
Homo sapiens