Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.28 extracted from

  • Wu, Q.; McLeish, M.J.
    Kinetic and pH studies on human phenylethanolamine N-methyltransferase (2013), Arch. Biochem. Biophys., 539, 1-8.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline i.e. SK&F 64139 Homo sapiens
7-nitro-1,2,3,4-tetrahydroisoquinoline
-
Homo sapiens
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine i.e. LY 134046 Homo sapiens
SKF 29661
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00054
-
3-trifluoromethylphenylethanolamine pH 8.0, 30°C Homo sapiens
0.0012
-
S-adenosyl-L-methionine cosubstrate 3-trifluoromethylphenylethanolamine, pH 8.0, 30°C Homo sapiens
0.0034
-
S-adenosyl-L-methionine cosubstrate phenylethanolamine, pH 8.0, 30°C Homo sapiens
0.0055
-
octopamine pH 8.0, 30°C Homo sapiens
0.0067
-
S-adenosyl-L-methionine cosubstrate octopamine, pH 8.0, 30°C Homo sapiens
0.1
-
phenylethanolamine pH 8.0, 30°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11086
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-trifluoromethylphenylethanolamine + S-adenosyl-L-methionine
-
Homo sapiens N-methyl-3-trifluoromethylphenylethanolamine + S-adenosyl-L-homocysteine
-
?
additional information enzyme operates by an ordered sequential mechanism in which AdoMet binds first. A protonated and an unprotonated group are required for catalysis Homo sapiens ?
-
?
octopamine + S-adenosyl-L-methionine
-
Homo sapiens N-methyloctopamine + S-adenosyl-L-homocysteine
-
?
phenylethanolamine + S-adenosyl-L-methionine
-
Homo sapiens N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.008
-
3-trifluoromethylphenylethanolamine pH 8.0, 30°C Homo sapiens
0.021
-
octopamine pH 8.0, 30°C Homo sapiens
0.047
-
phenylethanolamine pH 8.0, 30°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000016
-
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline pH 8.0, 30°C Homo sapiens
0.0000044
-
8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine pH 8.0, 30°C Homo sapiens
0.000078
-
7-nitro-1,2,3,4-tetrahydroisoquinoline pH 8.0, 30°C Homo sapiens
0.00012
-
SKF 29661 pH 8.0, 30°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.467
-
phenylethanolamine pH 8.0, 30°C Homo sapiens
3.67
-
octopamine pH 8.0, 30°C Homo sapiens
15.5
-
3-trifluoromethylphenylethanolamine pH 8.0, 30°C Homo sapiens