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Literature summary for 2.1.1.280 extracted from

  • McKenzie, M.; Hunter, D.; Pathirana, R.; Watson, L.; Joyce, N.; Matich, A.; Rowan, D.; Brummell, D.
    Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators (2009), Transgenic Res., 18, 407-424.
    View publication on PubMed
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Application

Application Comment Organism
agriculture transgenic expression in Nicotiana tabacum. When plants are watered with 200 microM selenate, overexpression of a selenocysteine methyltransferase transgene causes a 2- to 4fold increase in Se accumulation resulting in increased numbers of leaf lesions and areas of necrosis, production of methylselenocysteine up to 20% of total Se and generation of volatile dimethyl diselenide derived directly from methylselenocysteine. Despite the greatly increased accumulation of total Se, this does not result in increased Se toxicity effects on growth. Overexpression of ATP sulfurylase does not increase Se accumulation from selenate. Lines overexpressing both ATP sulfurylase and selenocysteine methyltransferase do not show a further increase in total Se accumulation or in leaf toxicity symptoms relative to overexpression of selenocysteine methyltransferase alone, but direct a greater proportion of Se into methylselenocysteine Astragalus bisulcatus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Nicotiana tabacum Astragalus bisulcatus

Protein Variants

Protein Variants Comment Organism
additional information transgenic expression in Nicotiana tabacum. When plants are watered with 200 microM selenate, overexpression of a selenocysteine methyltransferase transgene causes a 2- to 4fold increase in Se accumulation resulting in increased numbers of leaf lesions and areas of necrosis, production of methylselenocysteine up to 20% of total Se and generation of volatile dimethyl diselenide derived directly from methylselenocysteine. Despite the greatly increased accumulation of total Se, this does not result in increased Se toxicity effects on growth. Overexpression of ATP sulfurylase does not increase Se accumulation from selenate. Lines overexpressing both ATP sulfurylase and selenocysteine methyltransferase do not show a further increase in total Se accumulation or in leaf toxicity symptoms relative to overexpression of selenocysteine methyltransferase alone, but direct a greater proportion of Se into methylselenocysteine Astragalus bisulcatus

Organism

Organism UniProt Comment Textmining
Astragalus bisulcatus P56707
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