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Literature summary for 2.1.1.292 extracted from

  • Connors, N.C.; Bartel, P.L.; Strohl, W.R.
    Biosynthesis of anthracyclines: carminomycin 4-0-methyltransferase, the terminal enzymic step in the formation of daunomycin (1990), J. Gen. Microbiol., 136, 1895-1898.
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + carminomycin Streptomyces sp. with the corresponding aglycones, carminomycinone and 13-dihydrocarminomycinone, as substrates, no methylated products are detected. Other 4-hydroxyanthracyclines such as aklavin and aclacinomycin A, and 4-hydroxyanthracyclinones such as erhodomycinone and aklavinone, are not substrates for the 4-O-methyltransferase. These reaction specificities indicate that glycosylation of the anthracyclinone molecule must occur before 4-O-methylation, which means that 4-O-methylation of carminomycin is probably the terminal step in the biosynthesis of daunomycin, and that daunomycinone is not an intermediate in the pathway S-adenosyl-L-homocysteine + daunomycin
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Organism

Organism UniProt Comment Textmining
Streptomyces sp. Q55216
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 13-dihydrocarminomycin
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 Streptomyces sp. S-adenosyl-L-homocysteine + daunorubicinol
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 ?
S-adenosyl-L-methionine + carminomycin
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 Streptomyces sp. S-adenosyl-L-homocysteine + daunomycin
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 ?
S-adenosyl-L-methionine + carminomycin with the corresponding aglycones, carminomycinone and 13-dihydrocarminomycinone, as substrates, no methylated products are detected. Other 4-hydroxyanthracyclines such as aklavin and aclacinomycin A, and 4-hydroxyanthracyclinones such as erhodomycinone and aklavinone, are not substrates for the 4-O-methyltransferase. These reaction specificities indicate that glycosylation of the anthracyclinone molecule must occur before 4-O-methylation, which means that 4-O-methylation of carminomycin is probably the terminal step in the biosynthesis of daunomycin, and that daunomycinone is not an intermediate in the pathway Streptomyces sp. S-adenosyl-L-homocysteine + daunomycin
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 ?

Synonyms

Synonyms Comment Organism
COMT
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 Streptomyces sp.

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the terminal enzymic step in the formation of daunomycin Streptomyces sp.