Literature summary for 2.1.1.308 extracted from

Kuzuyama, T.; Hidaka, T.; Kamigiri, K.; Imai, S.; Seto, H.
Studies on the biosynthesis of fosfomycin. 4. The biosynthetic origin of the methyl group of fosfomycin (1992), J. Antibiot., 45, 1812-1814.

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Protein Variants

Protein Variants	Comment	Organism
additional information	a mutant of Streptomyces wedmorensis (A16), defective in the biosynthesis of cobalamin produces fosfomycin only in the presence of hydroxocobalamin. Incorporation of [14CH3]methylcobalamin into fosfomycin by the mutant A16	Streptomyces wedmorensis

Organism

Organism	UniProt	Comment	Textmining
Streptomyces wedmorensis	Q56184	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin	-	Streptomyces wedmorensis	(S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin	-	?

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Release 2023.1 (January 2023)