Application | Comment | Organism |
---|---|---|
medicine | oxidative stress induces apoptosis both via isoform PRMT1 in a SIRT1-dependent manner and via PRMT4 in a SIRT1-independent manner | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86X55 | isoform PRMT4 | - |
Homo sapiens | Q99873 | isoform PRMT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retinal pigment epithelial cell | retinal pigment epithelial cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CARM1 | - |
Homo sapiens |
PRMT1 | - |
Homo sapiens |
PRMT4 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | H2O2 treatment increases isoforms PRMT1 and PRMT4 expression but decreases sirtuin SIRT1 expression. Similar to H2O2 treatment, PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage | up |
General Information | Comment | Organism |
---|---|---|
physiological function | similar to H2O2 treatment, isoforms PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage. The H2O2-induced cell damage is attenuated by PRMT1 or PRMT4 knockdown and sirtuin SIRT1 overexpression | Homo sapiens |
physiological function | similar to H2O2 treatment, isoforms PRMT1 or PRMT4 overexpression increases retinal pigment epithelial cell damage. The H2O2-induced cell damage is attenuated by PRMT1 or PRMT4 knockdown and sirtuin SIRT1 overexpression. SIRT1 expression is regulated by PRMT1 | Homo sapiens |