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Literature summary for 2.1.1.319 extracted from

  • Zhang, H.; Han, C.; Li, T.; Li, N.; Cao, X.
    The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling (2019), Cell. Mol. Immunol., 16, 800-809 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.319

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q6NZB1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow-derived macrophage
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
PRMT6
-
 Mus musculus

General Information

General Information Comment Organism
malfunction PRMT6-deficient mice exhibit enhanced antiviral innate immunity. PRMT6 deficiency promotes the TBK1-IRF3 interaction and subsequently enhances IRF3 activation and type-I interferon production Mus musculus
physiological function the enzyme (PRMT6) attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling. Mechanistically, viral infection enhances the binding of PRMT6 to IRF3 and inhibited the interaction between IRF3 and TBK1. This mechanism is independent of PRMT6 methyltransferase activity Mus musculus