Literature summary for 2.1.1.319 extracted from

Qiao, X.; Kim, D.I.; Jun, H.; Ma, Y.; Knights, A.J.; Park, M.J.; Zhu, K.; Lipinski, J.H.; Liao, J.; Li, Y.; Richard, S.; Weinman, S.A.; Wu, J.
Protein arginine methyltransferase 1 interacts with PGC1alpha and modulates thermogenic fat activation (2019), Endocrinology, 160, 2773-2786 .

Search for more literature for 2.1.1.319

Application

Application	Comment	Organism
medicine	modulating PRMT1 activity may represent new avenues to regulate thermogenic fat and mediate energy homeostasis and may ultimately lead to therapeutic strategies against human obesity and associated metabolic disorders	Mus musculus
medicine	modulating PRMT1 activity may represent new avenues to regulate thermogenic fat and mediate energy homeostasis and may ultimately lead to therapeutic strategies against human obesity and associated metabolic disorders	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99873	-	-
Mus musculus	Q9JIF0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	Prmt1 is highly expressed in major metabolic organs and cell types, including thermogenic fat tissue and adipocytes	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PRMT1	-	Mus musculus
PRMT1	-	Homo sapiens
protein arginine methyltransferase 1	-	Mus musculus
protein arginine methyltransferase 1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	Prmt1 ablation in adipocytes impairs thermogenic activation induced by cold exposure or beta3-adrenergic stimulation. Loss of enzyme (PRMT1) in mature adipocytes does not affect adipose tissue function at basal level. Loss of PRMT1 or overexpression of PRMT1 does not affect adipogenesis in fat cells	Mus musculus
physiological function	enzyme (PRMT1) plays a regulatory role in thermogenic fat function	Mus musculus
physiological function	PRMT1 plays a regulatory role in thermogenic fat function	Homo sapiens

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Release 2023.1 (January 2023)