Literature summary for 2.1.1.319 extracted from

Araoi, S.; Daitoku, H.; Yokoyama, A.; Kako, K.; Hirota, K.; Fukamizu, A.
The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans (2018), J. Biochem., 163, 433-440 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	arginine methylation levels are increased when elt-2 is silenced, implying that erythroid-like transcription factor (ELT)-2 may have ability to inhibit methyltransferase activity of PRMT-1	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	Q9U2X0	-	-

Synonyms

Synonyms	Comment	Organism
PRMT-1	-	Caenorhabditis elegans
protein arginine methyltransferase 1	-	Caenorhabditis elegans

Expression

Organism	Comment	Expression
Caenorhabditis elegans	the GATA transcription factor elt-2 is a positive regulator of Pprmt-1:: gfp expression. elt-2 RNAi decreases endogenous PRMT-1 expression at mRNA and protein levels	down

General Information

General Information	Comment	Organism
malfunction	the null mutant of Caenorhabditis elegans prmt-1 is viable with no severe phenotype, despite loss of asymmetric arginine dimethylation	Caenorhabditis elegans
physiological function	the enzyme catalyzes asymmetric arginine dimethylation of cellular proteins and thus modulates various biological processes, including gene regulation, RNA metabolism, cell signaling and DNA repair	Caenorhabditis elegans

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Release 2023.1 (January 2023)