Application | Comment | Organism |
---|---|---|
medicine | PRMT1 and PRMT5 have opposing effects on chemotherapeutic agent-mediated apoptosis in lung cancer cells. The identification of PRMT5 and PRMT1 as CFLARL regulators involved in cellular apoptosis may help in developing new strategies to increase the sensitivity of cancer cells to chemotherapy, which may eventually benefit lung cancer treatments | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99873 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PRMT1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PRMT5 and PRMT1 are involved in the interaction between CFLARL (a CASP8 and FADD-like apoptosis regulator) and the E3 ligase ITCH. The PRMT5 silencing and PRMT1 overexpression enhance the interaction between CFLARL and ITCH, leading to an altered ubiquitination level and, eventually, the degradation of CFLARL | Homo sapiens |