Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q99873 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
protein arginine methyltransferase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the protein arginine methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells. Myc associates with both PRMT1 and PRMT5 being differentially dimethylated. Symmetric (S) by PRMT1 dimethylation protects Myc from degradation, while asymmetric (AS) dimethylation by PRMT5 allows Myc proper turnover. We hypothesize S-Myc as typical of aggressive glioblastoma stem cells, as S-Myc/AS-Myc ratio decreases in differentiating, less aggressive, cells | Homo sapiens |