Literature summary for 2.1.1.319 extracted from

Gou, Q.; He, S.; Zhou, Z.
Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells (2017), Tumour Biol., 39, 1010428317691419.

Search for more literature for 2.1.1.319

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99873	-	-

Synonyms

Synonyms	Comment	Organism
PRMT1	-	Homo sapiens
protein arginine N-methyltransferase I	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	protein arginine N-methyltransferase 1 expression is significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues	up

General Information

General Information	Comment	Organism
drug target	protein arginine N-methyltransferase 1 expression is significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues. Downregulation of protein arginine N-methyltransferase 1 in hepatocellular carcinoma cells by small interfering RNA could inhibit cell proliferation, migration, and invasion in vitro. The enzyme may contribute to hepatocellular carcinoma progression and serves as a promising target for the treatment of hepatocellular carcinoma patients	Homo sapiens
malfunction	knockdown of PRMT1 reverses epithelial-mesenchymal transition in HCC cell lines and inhibits the proliferation of HepG2 and Hep3B cells	Homo sapiens

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Release 2023.1 (January 2023)