Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NVM4 | isoform PRMT7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PRMT7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown of isoform PRMT5, EC 2.1.1.320, results in a reduction in symmetric dimethyl arginine modifcation of the SM protein set of small nuclear ribonucleoproteins. A similar effect is observed when cells are treated with siRNAs targeting methylosome protein MEP50. Isoform PRMT7 knockdown also causes a reduction in Sm protein symmetric dimethylarginine modification. Double depletion of both PRMT5 and PRMT7 does not disrupt the modification to a greater extent than either single depletion alone. PRMT7 is not able to restore symmetric dimethylarginine modification of the Sm proteins in cells that are depleted of PRMT5. Cytoplasmic small nuclear ribonucleoprotein assembly requires the activities of both PRMT5 and PRMT7, and Sm protein symmetric dimethylarginine modification is primarily required for cytoplasmic small nuclear ribonucleoprotein assembly | Homo sapiens |