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Literature summary for 2.1.1.321 extracted from

  • Vuong, T.A.; Jeong, H.J.; Lee, H.J.; Kim, B.G.; Leem, Y.E.; Cho, H.; Kang, J.S.
    PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation (2020), Cell Death Differ., 27, 15-28 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [protein]-L-arginine Mus musculus PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2 S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine
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Organism

Organism UniProt Comment Textmining
Mus musculus Q922X9
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [GLI2]-L-arginine PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2 Mus musculus S-adenosyl-L-homocysteine + [GLI2]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [protein]-L-arginine PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2 Mus musculus S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT7
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 Mus musculus
protein arginine methyltransferase 7
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 Mus musculus

General Information

General Information Comment Organism
malfunction PRMT7-deficient mouse embryonic fibroblasts (MEFs) exhibit a premature cellular senescence with accompanied increase in the cell cycle inhibitors p16 and p21. PRMT7 depletion results in reduced Shh signaling activity in MEFs Mus musculus
physiological function the enzyme (PRMT7) promotes Shh signaling via GLI2 methylation which is critical for suppression of cellular senescence. PRMT7 overexpression enhances GLI2-reporter activities that are sensitive to methylation inhibition. PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2. This methylation interferes with GLI2-SUFU binding, leading to facilitation of GLI2 nuclear accumulation and Shh signaling. PRMT7 induces GLI2 methylation, reducing its binding to SUFU and increasing Shh signaling, ultimately leading to prevention of cellular senescence Mus musculus