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Literature summary for 2.1.1.321 extracted from

  • Thakur, A.; Hevel, J.M.; Acevedo, O.
    Examining product specificity in protein arginine methyltransferase 7 (PRMT7) using quantum and molecular mechanical simulations (2019), J. Chem. Inf. Model., 59, 2913-2923 .
    View publication on PubMed
Search for more literature for 2.1.1.321

Protein Variants

Protein Variants Comment Organism
F71A the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme Trypanosoma brucei brucei
F71I the mutation of Phe71 to Ile converts the enzyme from a type III (mono)methyltransferase into a mixed type I/II, that is, an enzyme that can now perform dimethylation Trypanosoma brucei brucei
F71S the mutant preserves the type III (mono)methyltransferase behavior of the native enzyme Trypanosoma brucei brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei brucei Q582G4
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-
Trypanosoma brucei brucei 927 Q582G4
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Trypanosoma brucei brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [Ac-GGRGGFGGKGGCGGKGGFGGKGGFG peptide]-L-arginine peptides based on the Arg-Gly-Gly (RGG)-containing RNA binding proteins are substrates in the naked form but are not substrates in the monomethylated form Trypanosoma brucei brucei S-adenosyl-L-homocysteine + [Ac-GGRGGFGGKGGCGGKGGFGGKGGFG peptide]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [Ac-GGRGGFGGKGGCGGKGGFGGKGGFG peptide]-L-arginine peptides based on the Arg-Gly-Gly (RGG)-containing RNA binding proteins are substrates in the naked form but are not substrates in the monomethylated form Trypanosoma brucei brucei 927 S-adenosyl-L-homocysteine + [Ac-GGRGGFGGKGGCGGKGGFGGKGGFG peptide]-Nomega-methyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT7
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 Trypanosoma brucei brucei
protein arginine methyltransferase 7
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 Trypanosoma brucei brucei