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Literature summary for 2.1.1.34 extracted from

  • Watanabe, K.; Nureki, O.; Fukai, S.; Endo, Y.; Hori, H.
    Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues (2005), Nucleic Acids Symp. Ser., 49, 301-302.
    View publication on PubMed

Application

Application Comment Organism
analysis dissociation of tRNA from the tRNA-enzyme complex after the methyl-transfer reaction is caused by the dissociation of enzyme subunits Thermus thermophilus

Protein Variants

Protein Variants Comment Organism
R14M dissociation of subunits consistent with that from the wild-type enzyme Thermus thermophilus

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
-
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + tRNA
-
Thermus thermophilus S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
-
?
S-adenosyl-L-methionine + tRNA
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579 S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
-
?

Subunits

Subunits Comment Organism
homodimer in the absence of S-adenosyl-L-methionine or S-adenosyl-L-homocysteine Thermus thermophilus
monomer addition of S-adenosyl-L-homocysteine causes the dissociation of subunits and gives rise to a monomer structure Thermus thermophilus
tetramer in the presence of S-adenosyl-L-methionine Thermus thermophilus

Synonyms

Synonyms Comment Organism
transfer RNA (Gm18) methyltransferase
-
Thermus thermophilus
TrmH
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Thermus thermophilus
tRNA (Gm18) methyltransferase
-
Thermus thermophilus