Literature summary for 2.1.1.34 extracted from

Gehrig, S.; Eberle, M.E.; Botschen, F.; Rimbach, K.; Eberle, F.; Eigenbrod, T.; Kaiser, S.; Holmes, W.M.; Erdmann, V.A.; Sprinzl, M.; Bec, G.; Keith, G.; Dalpke, A.H.; Helm, M.
Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity (2012), J. Exp. Med., 209, 225-233.

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Application

Application	Comment	Organism
medicine	an RNA preparation of an Escherichia coli trmH mutant that lacks Gm18 2'-O-methyltransferase activity is significantly more immunostimulatory in human peripheral blood mononuclear cells than the wild-type sample. The single methyl group on the 2'-oxygen of Gm18 is a natural modification in native tRNA that, beyond its primary structural role, has acquired a secondary function as an antagonist of toll-like receptor TLR7	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

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Release 2023.1 (January 2023)