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Literature summary for 2.1.1.37 extracted from

  • Weyrich, A.; Tang, X.; Xu, G.; Schrattenholz, A.; Hunzinger, C.; Hennig, W.
    Mammalian DNMTs in the male germ line DNA of Drosophila (2008), Biochem. Cell Biol., 86, 380-385.
    View publication on PubMed
Search for more literature for 2.1.1.37

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of Dnmt3a and Dnmt3b Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information enzyme overexpression does not cause an altered phenotype Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Drosophila melanogaster the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
 isozymes Dnmt3a and Dnmt3b
-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell male Drosophila melanogaster
-
spermatid
-
 Drosophila melanogaster
-
spermatocyte primary Drosophila melanogaster
-
testis
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements Drosophila melanogaster DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
DNA + S-adenosyl-L-methionine substrate is genomic DNA of Drosophila melanogaster Drosophila melanogaster DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Synonyms

Synonyms Comment Organism
DNA (cytosine-5)-methyltransferase 3A
-
 Drosophila melanogaster
DNA (cytosine-5)-methyltransferase 3B
-
 Drosophila melanogaster
Dnmt3a
-
 Drosophila melanogaster
DNMT3B
-
 Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function the DNA methylation by the enzyme has no regulatory function for gene expression in Drosophile melnogaster Drosophila melanogaster