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Literature summary for 2.1.1.37 extracted from

  • Singh, N.; Duenas-Gonzalez, A.; Lyko, F.; Medina-Franco, J.L.
    Molecular modeling and molecular dynamics studies of hydralazine with human DNA methyltransferase 1 (2009), ChemMedChem, 4, 792-799.
    View publication on PubMed
Search for more literature for 2.1.1.37

Application

Application Comment Organism
drug development Dnmt inhibition is a promising strategy for the treatment of various developmental and proliferative diseases, particularly cancers Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-dC binding modelling, overview Homo sapiens
2'-deoxy-5-aza-cytidine binding modelling, overview Homo sapiens
5-azacytidine binding modelling, overview Homo sapiens
decitabine binding modelling, overview Homo sapiens
hydralazine binding modelling, overview Homo sapiens
additional information inhibitor screening by molecular docking and molecular dynamics simulations Homo sapiens
procainamide binding modelling, overview Homo sapiens
procaine binding modelling, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Homo sapiens
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine catalytic reaction mechanism of Dnmt1, overview Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
 Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
additional information homology docking and molecular dynamics, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More homology model for DNMT1 based on the template structures of the available comparable protein crystal structures, molecular dynamics, overview Homo sapiens

Synonyms

Synonyms Comment Organism
DNA methyltransferase 1
-
 Homo sapiens
Dnmt1
-
 Homo sapiens
More the enzyme belongs to the DNA methyltransferases, Dnmt, family of enzymes that methylates DNA at the C5 position of cytosine residues Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens