Cloned (Comment) | Organism |
---|---|
somatic Dnmt1 from liver, expression analysis of somatic and oocyte Dnmt1, recombinant expression in NIH3T3 cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromatin | the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner | Mus musculus | 785 | - |
nucleus | the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner | Mus musculus | 5634 | - |
pronucleus | the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner | Mus musculus | 45120 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
175000 | - |
somatic Dnmt1 | Mus musculus |
190000 | - |
oocyte Dnmt1 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Mus musculus | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female ICR mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Mus musculus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA (cytosine-5)-methyltransferase 1 | - |
Mus musculus |
DNA methyltransferase 1 | - |
Mus musculus |
Dnmt1o | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | DNA methylation at cytosine residues in CpG dinucleotides is a component of epigenetic marks crucial to mammalian development, maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1 | Mus musculus |