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Literature summary for 2.1.1.37 extracted from

  • Kurihara, Y.; Kawamura, Y.; Uchijima, Y.; Amamo, T.; Kobayashi, H.; Asano, T.; Kurihara, H.
    Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1 (2008), Dev. Biol., 313, 335-346.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
somatic Dnmt1 from liver, expression analysis of somatic and oocyte Dnmt1, recombinant expression in NIH3T3 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner Mus musculus 785
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nucleus the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner Mus musculus 5634
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pronucleus the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner Mus musculus 45120
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
175000
-
somatic Dnmt1 Mus musculus
190000
-
oocyte Dnmt1 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Mus musculus
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DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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female ICR mice
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte the somatic form of Dnmt1 is present in association with chromatin in MII-stage oocytes as well as in the nucleus throughout preimplantation development. At the early one-cell stage, somatic Dnmt1 is asymmetrically localized in the maternal pronuclei. Thereafter, somatic Dnmt1 is recruited to the paternal genome during pronuclear maturation. During the first two cell cycles after fertilization, Dnmt1s is exported from the nucleus in the G2 phase in a CRM1/exportin-dependent manner Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
Mus musculus DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?

Synonyms

Synonyms Comment Organism
DNA (cytosine-5)-methyltransferase 1
-
Mus musculus
DNA methyltransferase 1
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Mus musculus
Dnmt1o
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Mus musculus

General Information

General Information Comment Organism
physiological function DNA methylation at cytosine residues in CpG dinucleotides is a component of epigenetic marks crucial to mammalian development, maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1 Mus musculus