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Literature summary for 2.1.1.38 extracted from
- S-Adenosylmethionine: O-demethylpuromycin O-methyltransferase (1975), Methods Enzymol., 43, 508-515.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | product puromycin is an antibiotic and antitumor agent | Streptomyces alboniger |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + O-demethylpuromycin | Streptomyces alboniger | - |
S-adenosyl-L-homocysteine + puromycin | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces alboniger | - |
mutant strain ATCC 12462 | - |
| Streptomyces alboniger | - |
wild-type organism ATCC 12461 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces alboniger |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0165 | - |
- |
Streptomyces alboniger |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + O-demethylpuromycin | - |
Streptomyces alboniger | S-adenosyl-L-homocysteine + puromycin | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 38 | - |
very unstable at 38°C and pH 7.5 | Streptomyces alboniger |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | - |
Streptomyces alboniger |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
very unstable at pH 7.5 and 38°C | Streptomyces alboniger |
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