Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme also catalyzes the conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate | ? | - |
? | |
S-adenosyl-L-methionine + N-acetylserotonin | Homo sapiens | - |
S-adenosyl-L-homocysteine + melatonin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
the ASMT gene is spliced in an alternative way to form at least three possible isoforms | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pineal gland | - |
Homo sapiens | - |
retina | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme also catalyzes the conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate | Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + N-acetylserotonin | - |
Homo sapiens | S-adenosyl-L-homocysteine + melatonin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ASMT | - |
Homo sapiens |
hydroxyindole-O-methyltransferase | - |
Homo sapiens |
N-acetylserotonin O-methyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | all three isozymes are involved in the biosynthesis of melatonin. the enzyme is involved in a general tryptophan metabolism pathway where it catalyzes the final reaction in the production of melatonin, converting normelatonin to melatonin (a neurohormone). The conversion of 5-hydroxyindoleacetate to 5-methoxyindoleacetate in the same pathway is also catalyzed by this enzyme. In general tryptophan metabolism pathway, tryptophan functions as a biochemical precursor for serotonin | Homo sapiens |
additional information | structural homology molecular modeling and model evaluation, molecular dynamics simulation, overview. Active site determination and modeling of ligand binding by the enzyme | Homo sapiens |