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Literature summary for 2.1.1.41 extracted from
- Sterol methyl transferase: enzymology and inhibition (2000), Biochim. Biophys. Acta, 1529, 63-88.
Application
| Application | Comment | Organism |
|---|---|---|
| agriculture | construction of transgenic plants with modified sterol profile via recombinant sterol 24-C-methyltransferase shall protect crops against damage by insect infestation | Saccharomyces cerevisiae |
| agriculture | construction of transgenic plants with modified sterol profile via recombinant sterol 24-C-methyltransferase shall protect crops against damage by insect infestation | Candida albicans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (24R,S),25-epiminolanosterol | - |
Saccharomyces cerevisiae |  |
| (3beta,24,R,S)-24-methyl-24-thioniacholest-5-enol | - |
Candida albicans | |
| 24(S)-24-methyl-25-thiacholest-5-enol iodide | - |
Saccharomyces cerevisiae | |
| 25-Aza-24,25-dihydrozymosterol | - |
Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Saccharomyces cerevisiae | - |
- |
| microsome | - |
Candida albicans | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| zymosterol + S-adenosyl-L-methionine | Saccharomyces cerevisiae | role in biosynthesis of plant and fungi sterols | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
| zymosterol + S-adenosyl-L-methionine | Candida albicans | role in biosynthesis of plant and fungi sterols | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Saccharomyces cerevisiae |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | mechanism | Saccharomyces cerevisiae | |
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | mechanism | Candida albicans | |
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | active site model, termed steric-electric plug model, consists of a non-covalent mechanism involving the intermediacy of a 24beta-methyl (or ethyl) sterol bound to the ternary complex | Saccharomyces cerevisiae | |
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | active site model, termed steric-electric plug model, consists of a non-covalent mechanism involving the intermediacy of a 24beta-methyl (or ethyl) sterol bound to the ternary complex | Candida albicans | |
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | substrate binding, amino acid sequence | Saccharomyces cerevisiae | |
| S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol | substrate binding, amino acid sequence | Candida albicans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cycloartenol + S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | 24-methylenecycloartanol + S-adenosyl-L-homocysteine | - |
? | |
| cycloartenol + S-adenosyl-L-methionine | - |
Candida albicans | 24-methylenecycloartanol + S-adenosyl-L-homocysteine | - |
? | |
| lanosterol + S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine | - |
? | |
| lanosterol + S-adenosyl-L-methionine | - |
Candida albicans | 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine | - |
? | |
| zymosterol + S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
| zymosterol + S-adenosyl-L-methionine | - |
Candida albicans | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
| zymosterol + S-adenosyl-L-methionine | role in biosynthesis of plant and fungi sterols | Saccharomyces cerevisiae | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
| zymosterol + S-adenosyl-L-methionine | role in biosynthesis of plant and fungi sterols | Candida albicans | fecosterol + S-adenosyl-L-homocysteine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000003 | - |
25-Aza-24,25-dihydrozymosterol | - |
Saccharomyces cerevisiae | |
| 0.000016 | - |
(3beta,24,R,S)-24-methyl-24-thioniacholest-5-enol | - |
Candida albicans | |
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