Literature summary for 2.1.1.41 extracted from

Kaneshiro, E.S.; Johnston, L.Q.; Nkinin, S.W.; Romero, B.I.; Giner, J.L.
Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethionine:sterol C-24 methyltransferase (2015), J. Eukaryot. Microbiol., 62, 298-306.

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Organism

Organism	UniProt	Comment	Textmining
Pneumocystis carinii	Q96WX4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme transfers either one or two methyl groups to the C-24 position of the sterol side chain producing both C28 and C29 24-alkylsterols in approximately the same proportions	Pneumocystis carinii	?	-	?

Synonyms

Synonyms	Comment	Organism
Erg6	-	Pneumocystis carinii

General Information

General Information	Comment	Organism
physiological function	expression of the Pneumocystis carinii enzyme in a Saccharomyces cerevisiae erg6 knockout mutant restores its ability to produce the C28 sterol ergosterol as the major sterol, and also results in low levels of C29 sterols. In the yeast, the Pneumocystis carinii enzyme appears to be less able to add a second methyl group at the methylene function. In the transformed strain, ergosterol is the major sterol component comprising 75.2% of total sterols	Pneumocystis carinii

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Release 2023.1 (January 2023)