Application | Comment | Organism |
---|---|---|
medicine | possible target for chemotherapeutic attack | Trypanosoma brucei |
medicine | possible target for chemotherapeutic attack | Crithidia fasciculata |
medicine | possible target for chemotherapeutic attack | Trypanosoma cruzi |
medicine | possible target for chemotherapeutic attack | Trypanosoma congolense |
medicine | possible target for chemotherapeutic attack | Strigomonas oncopelti |
medicine | possible target for chemotherapeutic attack | Trypanosoma lewisi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | - |
Crithidia fasciculata | |
2-mercaptoethanol | - |
Strigomonas oncopelti | |
2-mercaptoethanol | - |
Trypanosoma brucei | |
2-mercaptoethanol | - |
Trypanosoma congolense | |
2-mercaptoethanol | - |
Trypanosoma cruzi | |
2-mercaptoethanol | - |
Trypanosoma lewisi | |
5-fluorouracil | - |
Crithidia fasciculata | |
5-fluorouracil | - |
Escherichia coli | |
5-fluorouracil | - |
Trypanosoma cruzi | |
aminopterin | - |
Crithidia fasciculata | |
aminopterin | - |
Trypanosoma cruzi | |
antrycide | - |
Crithidia fasciculata | |
antrycide | - |
Strigomonas oncopelti | |
antrycide | - |
Trypanosoma brucei | |
antrycide | - |
Trypanosoma congolense | |
antrycide | - |
Trypanosoma cruzi | |
antrycide | - |
Trypanosoma lewisi | |
dimidium | - |
Crithidia fasciculata | |
dimidium | - |
Strigomonas oncopelti | |
dimidium | - |
Trypanosoma brucei | |
dimidium | - |
Trypanosoma congolense | |
dimidium | - |
Trypanosoma cruzi | |
dimidium | - |
Trypanosoma lewisi | |
ethidium | - |
Crithidia fasciculata | |
ethidium | - |
Strigomonas oncopelti | |
ethidium | - |
Trypanosoma brucei | |
ethidium | - |
Trypanosoma congolense | |
ethidium | - |
Trypanosoma cruzi | |
ethidium | - |
Trypanosoma lewisi | |
Mg2+ | - |
Crithidia fasciculata | |
Mg2+ | - |
Strigomonas oncopelti | |
Mg2+ | - |
Trypanosoma brucei | |
Mg2+ | - |
Trypanosoma congolense | |
Mg2+ | - |
Trypanosoma cruzi | |
Mg2+ | - |
Trypanosoma lewisi | |
Pentamidine | - |
Crithidia fasciculata | |
Pentamidine | - |
Strigomonas oncopelti | |
Pentamidine | - |
Trypanosoma brucei | |
Pentamidine | - |
Trypanosoma congolense | |
Pentamidine | - |
Trypanosoma cruzi | |
Pentamidine | - |
Trypanosoma lewisi | |
prothidium | - |
Crithidia fasciculata | |
prothidium | - |
Strigomonas oncopelti | |
prothidium | - |
Trypanosoma brucei | |
prothidium | - |
Trypanosoma congolense | |
prothidium | - |
Trypanosoma cruzi | |
prothidium | - |
Trypanosoma lewisi | |
suramin | - |
Crithidia fasciculata | |
suramin | - |
Strigomonas oncopelti | |
suramin | - |
Trypanosoma brucei | |
suramin | - |
Trypanosoma congolense | |
suramin | - |
Trypanosoma cruzi | |
suramin | - |
Trypanosoma lewisi | |
trimethoprim | - |
Crithidia fasciculata | |
trimethoprim | - |
Trypanosoma cruzi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
175000 | - |
gel filtration | Crithidia fasciculata |
200000 | - |
gel filtration | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | Escherichia coli | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Rattus norvegicus | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Trypanosoma brucei | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Crithidia fasciculata | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Trypanosoma cruzi | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Trypanosoma congolense | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Strigomonas oncopelti | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Trypanosoma lewisi | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Trypanosoma brucei gambiense | - |
dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | Trypanosoma rhodesiense | - |
dihydrofolate + dTMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
host Anopheles strain ATCC 11,745 | - |
Escherichia coli | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Strigomonas oncopelti | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Trypanosoma brucei gambiense | - |
- |
- |
Trypanosoma congolense | - |
causes nagana, the equivalent disease of cattle | - |
Trypanosoma cruzi | - |
sonya strain, maintained in ASH/XP mice | - |
Trypanosoma cruzi | - |
causes Chagas' disease in man | - |
Trypanosoma lewisi | - |
natural pathogen of rats | - |
Trypanosoma rhodesiense | - |
causes human sleeping sickness | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | intracellular parasites, host blood | Trypanosoma brucei | - |
blood | intracellular parasites, host blood | Crithidia fasciculata | - |
blood | intracellular parasites, host blood | Trypanosoma cruzi | - |
blood | intracellular parasites, host blood | Trypanosoma congolense | - |
blood | intracellular parasites, host blood | Strigomonas oncopelti | - |
blood | intracellular parasites, host blood | Trypanosoma lewisi | - |
blood | obtained from infected rat blood | Trypanosoma brucei | - |
blood | obtained from infected rat blood | Trypanosoma congolense | - |
blood | obtained from infected rat blood | Trypanosoma lewisi | - |
fetus | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00012 | - |
- |
Trypanosoma brucei |
0.00014 | - |
- |
Trypanosoma congolense |
0.00035 | - |
intracellular form | Trypanosoma cruzi |
0.00038 | - |
- |
Trypanosoma lewisi |
0.00054 | - |
- |
Strigomonas oncopelti |
0.00119 | - |
blood form | Trypanosoma cruzi |
0.00156 | - |
culture form | Trypanosoma cruzi |
0.00218 | - |
- |
Crithidia fasciculata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma brucei | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma brucei | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Crithidia fasciculata | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Crithidia fasciculata | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma cruzi | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma cruzi | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma congolense | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma congolense | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Strigomonas oncopelti | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Strigomonas oncopelti | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma lewisi | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma lewisi | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma brucei gambiense | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma brucei gambiense | dihydrofolate + dTMP | - |
r | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma rhodesiense | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Trypanosoma rhodesiense | dihydrofolate + dTMP | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Crithidia fasciculata |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 6.7 | - |
Trypanosoma lewisi |
6.5 | 6.7 | - |
Trypanosoma brucei gambiense |
7.8 | - |
- |
Crithidia fasciculata |