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Literature summary for 2.1.1.45 extracted from

  • Fox, K.M.; Maley, F.; Garibian, A.; Changchien, L.M.; Van Roey, P.
    Crystal structure of thymidylate synthase A from Bacillus subtilis (1999), Protein Sci., 8, 538-544.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.45

Cloned(Commentary)

Cloned (Comment) Organism
contains 2 genes for thymidilate synthase, ThyA and ThyB Bacillus subtilis

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Bacillus subtilis
-
 dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP Escherichia coli
-
 dihydrofolate + dTMP
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Bacillus subtilis dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP
-
 Bacillus subtilis dihydrofolate + dTMP
-
 r
5,10-methylenetetrahydrofolate + dUMP
-
 Escherichia coli dihydrofolate + dTMP
-
 ?
5,10-methylenetetrahydrofolate + dUMP
-
 Escherichia coli dihydrofolate + dTMP
-
 r

Subunits

Subunits Comment Organism
dimer
-
 Bacillus subtilis
dimer
-
 Escherichia coli