Literature summary for 2.1.1.45 extracted from

Jarmula, A.; Dowiercial, A.; Rode, W.
A molecular modeling study of the interaction of 2-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase (2008), Bioorg. Med. Chem. Lett., 18, 2701-2708.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2',5-difluoro-ara-UMP	slow-binding (time-dependent) inhibitor	Escherichia coli
2'-deoxy-2',2'-difluorouridine 5'-dihydrogen	classic inhibitor (no time dependence of inhibition observed)	Escherichia coli
2'-fluoro-ara-UMP	classic inhibitor (no time dependence of inhibition observed)	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A884	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	-	Escherichia coli	dihydrofolate + dTMP	-	?

Cofactor

Cofactor	Comment	Organism	Structure
N5,N10-methylenetetrahydrofolate	-	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00477	-	2',5-difluoro-ara-UMP	-	Escherichia coli
0.0103	-	2'-fluoro-ara-UMP	-	Escherichia coli
0.4328	-	2'-deoxy-2',2'-difluorouridine 5'-dihydrogen	-	Escherichia coli

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Release 2023.1 (January 2023)