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Literature summary for 2.1.1.45 extracted from

  • Showalter, S.L.; Showalter, T.N.; Witkiewicz, A.; Havens, R.; Kennedy, E.P.; Hucl, T.; Kern, S.E.; Yeo, C.J.; Brody, J.R.
    Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward? (2008), Cancer Biol. Ther., 7, 986-994.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
5-fluoropyrimidine-2,4(1H,3H)-dione
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
Homo sapiens dihydrofolate + dTMP
-
?

Cofactor

Cofactor Comment Organism Structure
N5,N10-methylenetetrahydrofolate
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens there is an approximately 2fold inverse relationship between thymidylate synthase expression and response to 5-fluoruracil down