Literature summary for 2.1.1.45 extracted from

Zhang, Y.; Yang, S.; Liu, M.; Song, C.; Wu, N.; Ling, P.; Chu, E.; Lin, X.
Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos (2010), PLoS ONE, 5, e10618.

Search for more literature for 2.1.1.45

General Stability

General Stability	Organism
treatment of zebrafish embryos with 5-fluorouracil increases the enzyme stability significantly, the half life of enzyme protein is about 2.7 times longer than in untreated embryos	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Danio rerio	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	-	Danio rerio	dihydrofolate + dTMP	-	?
additional information	the enzyme is specifically bound with its cognate mRNA in vitro and in vivo	Danio rerio	?	-	?

Expression

Organism	Comment	Expression
Danio rerio	the expression of thymidylate synthase is increased by about 6fold when embryos are treated with 0.001 mM 5-fluorouracil and there is a greater than 10fold increase in the enzyme protein level after treatment with 0.0004 mM ZD1694	up

General Information

General Information	Comment	Organism
physiological function	the enzyme is indispensable for DNA replication in actively dividing cells	Danio rerio

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Release 2023.1 (January 2023)