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Literature summary for 2.1.1.49 extracted from

  • Bahnmaier, A.H.; Woesle, B.; Thomas, H.
    Stereospecific N-methylation of the tetrahydroisoquinoline alkaloids isosalsoline and salsolidine by amine N-methyltransferase A from bovine liver (1999), Chirality, 11, 160-165.
    View publication on PubMed
Search for more literature for 2.1.1.49

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-isosalsoline + methyl group donor Bos taurus
-
 N-methyl-(R)-isosalsoline + demethylated methyl group donor N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 amine N-methyltransferase A
-

Purification (Commentary)

Purification (Comment) Organism
amine N-methyltransferase A Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000012
-
 N-methyltransferase A, (-)-(S)-isosalsoline Bos taurus
0.0000021
-
 N-methyltransferase A, (-)-(S)-salsolidine Bos taurus
0.0000033
-
 N-methyltransferase A, (+)-(R)-isosalsoline Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-isosalsoline + methyl group donor
-
 Bos taurus N-methyl-(R)-isosalsoline + demethylated methyl group donor N-methyl-(R)-isosalsoline is enzymatically formed in liver and can be transported into the brain from blood, it may act as neurotransmitter ?
S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline amine N-methyltransferase A Bos taurus S-adenosyl-L-homocysteine + N-methyl-1,2,3,4-tetrahydroisoquinoline
-
 ?
S-adenosyl-L-methionine + isosalsoline isosalsoline is identical with 7-hydroxy-6-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (+)-(R)-enantiomer is preferentially methylated Bos taurus S-adenosyl-L-homocysteine + N-methylisosalsoline
-
 ?
S-adenosyl-L-methionine + salsolidine salsolidine is identical with 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, stereospecific N-methylation by amine N-methyltransferase A, (-)-(S)-enantiomer is preferentially methylated Bos taurus S-adenosyl-L-homocysteine + N-methylsalsolidine
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus