Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | biosynthesis of enzyme is induced in response to obstructive jaundice | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
28.3 | - |
tryptamine | mitochondrial enzyme, cholestatic liver, S-adenosyl-L-methionine | Rattus norvegicus | |
32.5 | - |
tryptamine | mitochondrial enzyme, control liver, S-adenosyl-L-methionine | Rattus norvegicus | |
34.1 | - |
tryptamine | microsomal enzyme, cholestatic liver, S-adenosyl-L-methionine | Rattus norvegicus | |
35.6 | - |
tryptamine | microsomal enzyme, control liver, S-adenosyl-L-methionine | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | liver | Rattus norvegicus | 5829 | - |
membrane | hepatic membrane-bound enzyme | Rattus norvegicus | 16020 | - |
microsome | liver | Rattus norvegicus | - |
- |
mitochondrion | liver | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + an amine | Rattus norvegicus | xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis | S-adenosyl-L-homocysteine + an N-methylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley strain male rats | - |
Rattus norvegicus | - |
rats with common bile duct ligation and obstructive jaundice respectively | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
liver | investigation of enzyme in cholestatic liver, induced by common bile duct ligation for a period of 42 days | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
salivary gland | - |
Rattus norvegicus | - |
serum | investigation of enzyme in serum, after common bile duct ligation for a period of 42 days | Rattus norvegicus | - |
small intestine | - |
Rattus norvegicus | - |
stomach | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
specific activities of serum, control and cholestatic liver in cytosolic, mitochondrial and microsomal preparations for 0.5, 1, 2, 3, 7, 14, 28 and 42 days after common bile duct ligation, activities of mitochondrial and microsomal enzyme in cholestatic liver and of serum enzyme increase after common bile duct ligation, Vmax-values | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + an amine | xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis | Rattus norvegicus | S-adenosyl-L-homocysteine + an N-methylamine | - |
? | |
S-adenosyl-L-methionine + tryptamine | S-adenosyl-L-methionine-dependent enzyme | Rattus norvegicus | S-adenosyl-L-homocysteine + alpha-N-methyltryptamine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Rattus norvegicus |