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Literature summary for 2.1.1.5 extracted from

  • Schaefer, C.; Hoffmann, L.; Heldt, K.; Lornejad-Schaefer, M.R.; Brauers, G.; Gehrmann, T.; Garrow, T.A.; Haeussinger, D.; Mayatepek, E.; Schwahn, B.C.; Schliess, F.
    Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells (2007), Am. J. Physiol. Gastrointest. Liver Physiol., 292, G1089-G1098.
    View publication on PubMed
Search for more literature for 2.1.1.5

Activating Compound

Activating Compound Comment Organism Structure
additional information after 24 h, Bhmt expression increases 1.53fold under hypoosmotic conditions, Bhmt enzymatic activity is altered under anisoosmotic conditions Rattus norvegicus

Application

Application Comment Organism
molecular biology osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally lead to metabolic alterations that depend on the availability of betaine-derived methyl groups Rattus norvegicus
additional information Bhmt expression is strongly regulated by changes in ambient osmolarity, osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally leads to metabolic alterations that depend on the availability of betaine-derived methyl groups Mus musculus
additional information Bhmt expression is strongly regulated by changes in ambient osmolarity, osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally leads to metabolic alterations that depend on the availability of betaine-derived methyl groups Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
actinomycin D leads to a decay of Bhmt mRNA, irrespective of the ambient osmolarity, at 120 min after addition, Bhmt mRNA levels are significantly decreased under hyperosmotic conditions, compared with the Bhmt mRNA levels found under the respective normo- or hypoosmotic condition Rattus norvegicus
additional information osmosensitivity of Bhmt mRNA expression Mus musculus
additional information hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression, suggesting that cell shrinkage rather than increased ionic strength or hyperosmolarity per se is the trigger, osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male B57CL/6 mice
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Rattus norvegicus
-
-
-
Rattus norvegicus O09171
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-

Source Tissue

Source Tissue Comment Organism Textmining
H4IIE cell
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 Rattus norvegicus
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hepatocyte
-
 Mus musculus
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hepatoma cell line hyperosmolarity (405 mosmol/l) suppresses Bhmt mRNA expression whereas hypoosmotic (205 mosmol/l) conditions induce Bhmt mRNA expression. Like hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression. Osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases Rattus norvegicus
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liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-homocysteine + betaine
-
 Rattus norvegicus L-methionine + dimethylglycine
-
 ?

Synonyms

Synonyms Comment Organism
betaine-homocysteine S-methyltransferase
-
 Rattus norvegicus
BHMT
-
 Mus musculus
BHMT
-
 Rattus norvegicus