Literature summary for 2.1.1.5 extracted from

Collinsova, M.; Strakova, J.; Jiracek, J.; Garrow, T.A.
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice (2006), J. Nutr., 136, 1493-1497.

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Application

Application	Comment	Organism
medicine	transient inhibition of BHMT in vivo causes transient hyperhomocysteinemia	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
S-(delta-Carboxybutyl)-DL-homocysteine	0.005 mM reduces BHMT activity ca. 95% in the standard assay that contains high levels (0.0025 mM) of L-homocysteine. Compared with saline-injected control mice, at 2 h postinjection, mice have 87% lower BHMT activity and a 2.7fold increase in plasma total homocysteine, effects that last nearly 8 h but return to normal by 24 h, level of BHMT protein remains constant over the 24-h period. After 6 injections (one every 12 h), the mice have 7fold higher plasma total homocysteine, a 65% reduction in the liver S-adenosylmethionine: S-adenosylhomocysteine ratio, and a marked upregulation of BHMT protein expression. When methionine is injected, postmethionine load plasma total homocysteine levels are 2.2fold higher at 2 h postinjection	Mus musculus
S-(delta-carboxybutyl)-DL-homocysteine-sulfoxide	at 2 h after injection, there is a modest reduction in BHMT activity and a 90% increase in plasma total homocysteine	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	6-week-old Balb/C male mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
BHMT	-	Mus musculus

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Release 2023.1 (January 2023)