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Literature summary for 2.1.1.56 extracted from

  • Pugh, C.S.G.; Borchardt, R.T.
    Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation (1982), Biochemistry, 21, 1535-1541.
    View publication on PubMed
Search for more literature for 2.1.1.56

Inhibitors

Inhibitors Comment Organism Structure
5',N8-Adenosyl-alpha,beta-diaminobutyric acid moderate Vaccinia virus
amino acid modified structure analogue of adenosyl-L-homocysteine i.e. A9145C, strong Vaccinia virus
additional information no inhibition by S-uridinyl-L-homocysteine, S-cytidinyl-L-homocysteine Vaccinia virus
S-(2-azaadenosyl)-L-homocysteine moderate Vaccinia virus
S-(3-Aminoadenosyl)-L-homocysteine weak Vaccinia virus
S-(3-deazaadenosyl)-L-homocysteine strong Vaccinia virus
S-(8-azaadenosyl)-L-homocysteine weak Vaccinia virus
S-(N6-Dimethyl-3-deazaadenosyl)-L-homocysteine weak Vaccinia virus
S-(N6-Methyladenosyl)-L-homocysteine moderate Vaccinia virus
S-Adenosyl-D-homocysteine weak Vaccinia virus
S-adenosyl-L-cysteine moderate Vaccinia virus
S-adenosyl-L-homocysteine product inhibition, competitive Vaccinia virus
S-Adenosyl-L-homocysteine structural analogues
-
 Vaccinia virus
S-Adenosyl-L-homocysteine sulfone weak Vaccinia virus
S-adenosyl-L-homocysteine sulfoxide weak Vaccinia virus
S-Aristeromycinyl-L-homocysteine
-
 Vaccinia virus
S-Inosyl-L-homocysteine weak Vaccinia virus
S-Tubercidinyl-L-homocysteine weak Vaccinia virus
sinefungin i.e. A9145, strong Vaccinia virus

Localization

Localization Comment Organism GeneOntology No. Textmining
viral nucleocapsid
-
 Vaccinia virus 19013
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA Vaccinia virus R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?
S-adenosyl-L-methionine + G(5')pppR-RNA Vaccinia virus WR R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?

Organism

Organism UniProt Comment Textmining
Vaccinia virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA
-
 Vaccinia virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA R may be guanosine or adenosine, mRNA containing an N7-methylguanine cap ?
S-adenosyl-L-methionine + G(5')pppR-RNA R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA Vaccinia virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?
S-adenosyl-L-methionine + G(5')pppR-RNA
-
 Vaccinia virus WR S-adenosyl-L-homocysteine + m7G(5')pppR-RNA R may be guanosine or adenosine, mRNA containing an N7-methylguanine cap ?
S-adenosyl-L-methionine + G(5')pppR-RNA R may be guanosine or adenosine, involved in synthesis of methylated capped structure at 5'-terminal of viral mRNA Vaccinia virus WR S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Vaccinia virus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Vaccinia virus