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Literature summary for 2.1.1.56 extracted from

  • Wen, Y.; Shatkin, A.J.
    Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha (2000), Genes Dev., 14, 2944-2949.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.56

Activating Compound

Activating Compound Comment Organism Structure
importin-alpha enhances specific binding of the enzyme to RNA, enhances RNA modification activity in vivo and in vitro Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of full length enzyme and truncated enzyme in yeast and in HeLa cells, His-tagged, as GFP-fusion protein, or cMyc-tagged Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GpppG inhibits binding of the enzyme to RNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus GFP-fusion protein analysis Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA
-
 Homo sapiens S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
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