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Literature summary for 2.1.1.56 extracted from

  • Zhang, X.; Wei, Y.; Ma, Y.; Hu, S.; Li, J.
    Identification of aromatic amino acid residues in conserved region VI of the large polymerase of vesicular stomatitis virus is essential for both guanine-N-7 and ribose 2-O methyltransferases (2010), Virology, 408, 241-252.
    View publication on PubMed
Search for more literature for 2.1.1.56

Protein Variants

Protein Variants Comment Organism
E1764A mutation abolishes both guanine-N-7 (G-N-7) and ribose 2'-O methylation methylation vesicular stomatitis virus
F1691A mutation abolishes both guanine-N-7 (G-N-7) and ribose 2'-O methylation. Alanine substitution results in recombinant virus that does not form plaques and significant diminished viral replication vesicular stomatitis virus
F1691W mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 82% of wild-type guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
F1691Y mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 85% of wild-type guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
F1745A mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
F1816A mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
L1757A mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
N1692A mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
P1709A mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
S1693A mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
S1827A mutant shows a moderate defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
W1744A mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
Y1650A mutation abolishes both guanine-N-7 (G-N-7) and ribose 2'-O methylation. Alanine substitution results in recombinant virus that does not form plaques and significant diminished viral replication vesicular stomatitis virus
Y1650F mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 88% of wild-type guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
Y1650W mutation does not significantly affect the size of viral plaques. Mutant replicates as wild-type VSV. Mutant exhibits 90% of wild-type guanine-N-7 (G-N-7) methylation vesicular stomatitis virus
Y1835A mutant does not show a significant defect in guanine-N-7 (G-N-7) methylation vesicular stomatitis virus

Organism

Organism UniProt Comment Textmining
vesicular stomatitis virus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + G(5')pppR-RNA
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 vesicular stomatitis virus S-adenosyl-L-homocysteine + m7G(5')pppR-RNA
-
 ?

Synonyms

Synonyms Comment Organism
guanine-N-7 methyltransferase
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 vesicular stomatitis virus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 vesicular stomatitis virus