Protein Variants | Comment | Organism |
---|---|---|
C382Y | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
C414R | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
C416R | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
D331A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
D331Y | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
D352A | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
F73A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
G333A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
I332A | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
K336A | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
L419R | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
P335A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
R310A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
R84A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
T428A | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
W86A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
Y368A | mutation abolishes the N7-MTase activity on GTP | Severe acute respiratory syndrome-related coronavirus |
Y420A | 15-50% of wild-type activity | Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome-related coronavirus | P0C6X7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no substrates: ATP, CTP, UTP, dATP, dCTP, dUTP or cap analog m7GpppA | Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
S-adenosyl-L-methionine + dGTP | and G(5')pppG, best substrates | Severe acute respiratory syndrome-related coronavirus | S-adenosyl-L-homocysteine + m7dGTP | - |
? | |
S-adenosyl-L-methionine + G(5')pppA | - |
Severe acute respiratory syndrome-related coronavirus | S-adenosyl-L-homocysteine + m7G(5')pppA | - |
? | |
S-adenosyl-L-methionine + G(5')pppG | and dGTP, best substrates | Severe acute respiratory syndrome-related coronavirus | S-adenosyl-L-homocysteine + m7G(5')pppG | - |
? | |
S-adenosyl-L-methionine + GTP | - |
Severe acute respiratory syndrome-related coronavirus | S-adenosyl-L-homocysteine + m7GTP | - |
? | |
S-adenosyl-L-methionine + m7G(5')pppG | - |
Severe acute respiratory syndrome-related coronavirus | S-adenosyl-L-homocysteine + ? | - |
? |