Literature summary for 2.1.1.57 extracted from

Li, J.; Fontaine-Rodriguez, E.C.; Whelan, S.P.
Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity (2005), J. Virol., 79, 13373-13384.

Search for more literature for 2.1.1.57

Application

Application	Comment	Organism
additional information	domain VI of vesicular stomatitis virus L protein functions as a methyltransferase, active-site residues K1651, D1762, K1795, and E1833 within domain VI are essential for mRNA cap methylation	vesicular stomatitis virus

Cloned(Commentary)

Cloned (Comment)	Organism
transfection of BHK-21 cells	vesicular stomatitis virus

Protein Variants

Protein Variants	Comment	Organism
D1762A	with pinpoint plaque morphologies and replication defects in single-step growth assays, viral RNA and protein synthesis is diminished	vesicular stomatitis virus
E1833A	with pinpoint plaque morphologies and most significant replication defects in single-step growth assays, viral RNA and protein synthesis is diminished	vesicular stomatitis virus
E1833Q	delay in replication	vesicular stomatitis virus
G1674A	does not significantly perturb viral growth and gene expression, replicates with almost indistinguishable kinetics to recombinant vesicular stomatitis virus	vesicular stomatitis virus
K1651A	with pinpoint plaque morphologies and most significant replication defects in single-step growth assays, viral RNA and protein synthesis is diminished	vesicular stomatitis virus
K1795A	most significant defect in replication	vesicular stomatitis virus
K1795A	with pinpoint plaque morphologies and replication defects in single-step growth assays, viral RNA and protein synthesis is diminished	vesicular stomatitis virus

Organism

Organism	UniProt	Comment	Textmining
vesicular stomatitis virus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by centrifugation	vesicular stomatitis virus

Synonyms

Synonyms	Comment	Organism
mRNA cap methyltransferase	-	vesicular stomatitis virus

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Release 2023.1 (January 2023)