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Literature summary for 2.1.1.6 extracted from
- An assay for determination of rat adrenal catechol-O-methyltransferase activity: comparison of spontaneously hypertensive rats and Wistar-Kyoto rats (2004), Anal. Bioanal. Chem., 380, 887-890.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00501 | - |
S-adenosyl-L-methionine | membrane-bound activity | Rattus norvegicus |  |
| 0.00863 | - |
S-adenosyl-L-methionine | soluble activity | Rattus norvegicus | |
| 0.009 | - |
epinephrine | membrane-bound activity | Rattus norvegicus | |
| 0.59 | 1 | epinephrine | soluble activity | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound to, MB-COMT | Rattus norvegicus | 16020 | - |
| soluble | S-COMT | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | Km: 0.21 mM for soluble activity, Km: 0.15 mM for membrane-bound activity | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | COMT in the adrenal gland might not be related to blood pressure regulation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | COMT in the adrenal gland might not be related to blood pressure regulation | Rattus norvegicus | ? | - |
? | |
| S-adenosyl-L-methionine + epinephrine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + metanephrine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COMT | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
membrane-bound activity | Rattus norvegicus |
| 7.8 | - |
soluble activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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