Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-epicatechin-3-gallate | IC50: 0.0002 mM with 2-hydroxyestradiol as substrate, IC50: 0.0003 mM with 4-hydroxyestradiol as substrate | Homo sapiens | |
(-)-epigallocatechin | IC50: 0.044 mM with 2-hydroxyestradiol as substrate, IC50: 0.05 nM with 4-hydroxyestradiol as substrate | Homo sapiens | |
(-)-epigallocatechin-3-gallate | IC50: 70 nM with 2-hydroxyestradiol as substrate, IC50: 80 nM with 4-hydroxyestradiol as substrate, mixed inhibitor | Homo sapiens | |
(-)-epigallocatechin-3-gallate-3''-O-glucuronide | IC50: 0.002 mM with 2-hydroxyestradiol as substrate, IC50: 0.0025 mM with 4-hydroxyestradiol as substrate | Homo sapiens | |
(-)-epigallocatechin-3-gallate-3'-O-glucuronide | IC50: 0.0018 mM with 2-hydroxyestradiol as substrate, IC50: 0.0023 mM with 4-hydroxyestradiol as substrate | Homo sapiens | |
(-)-epigallocatechin-3-gallate-4''-O-glucuronide | IC50: 0.0025 mM with 2-hydroxyestradiol as substrate, IC50: 0.004 mM with 4-hydroxyestradiol as substrate | Homo sapiens | |
(-)-epigallocatechin-3-gallate-7-O-glucuronide | IC50: 600 nM with 2-hydroxyestradiol as substrate, IC50: 800 nM with 4-hydroxyestradiol as substrate | Homo sapiens | |
(-)epicatechin | IC50: 0.06 mM with 2-hydroxyestradiol as substrate, IC50: 0.08 mM with 4-hydroxyestradiol as substrate | Homo sapiens | |
4'-4''-di-O-methyl-epigallocatechin-3-gallate | IC50: 0.00015 mM with 2-hydroxyestradiol or 4-hydroxyestradiol as substrate, competitive with respect S-adenyosylmethionine, noncompetitive with respect to catechol | Homo sapiens | |
4'-O-methyl-(-)-epigallocatechin | IC50: 0.032 mM with 2-hydroxyestradiol as substrate, IC50: 0.04 mM with 4-hydroxyestradiol as substrate | Homo sapiens | |
4'-O-methyl-epigallocatechin-3-gallate | IC50: 0.0001 mM with 2-hydroxyestradiol or 4-hydroxyestradiol as substrate | Homo sapiens | |
additional information | no inhibition by genistein, daidzein and biochanin A | Homo sapiens | |
quercetin | IC50: 0.0085 mM with 2-hydroxyestradiol or 4-hydroxyestradiol as substrate | Homo sapiens | |
S-adenosyl-L-methionine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00032 | - |
2-hydroxyestradiol | - |
Homo sapiens | |
0.00037 | - |
4-hydroxyestradiol | - |
Homo sapiens | |
0.0172 | - |
S-adenosyl-L-methionine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 2-hydroxyestradiol | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 4-hydroxyestradiol | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + epigallocatechin-3-gallate | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00032 | - |
(-)-epigallocatechin-3-gallate | substrate: 2-hydroxyestradiol | Homo sapiens | |
0.00037 | - |
(-)-epigallocatechin-3-gallate | substrate: 4-hydroxyestradiol | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00007 | - |
IC50: 70 nM with 2-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin-3-gallate | |
0.00008 | - |
IC50: 80 nM with 4-hydroxyestradiol as substrate, mixed inhibitor | Homo sapiens | (-)-epigallocatechin-3-gallate | |
0.0001 | - |
IC50: 0.0001 mM with 2-hydroxyestradiol or 4-hydroxyestradiol as substrate | Homo sapiens | 4'-O-methyl-epigallocatechin-3-gallate | |
0.00015 | - |
IC50: 0.00015 mM with 2-hydroxyestradiol or 4-hydroxyestradiol as substrate, competitive with respect S-adenyosylmethionine, noncompetitive with respect to catechol | Homo sapiens | 4'-4''-di-O-methyl-epigallocatechin-3-gallate | |
0.0003 | - |
IC50: 0.0002 mM with 2-hydroxyestradiol as substrate, IC50: 0.0003 mM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)-epicatechin-3-gallate | |
0.0006 | - |
IC50: 600 nM with 2-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin-3-gallate-7-O-glucuronide | |
0.0008 | - |
IC50: 800 nM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin-3-gallate-7-O-glucuronide | |
0.0023 | - |
IC50: 0.0018 mM with 2-hydroxyestradiol as substrate, IC50: 0.0023 mM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin-3-gallate-3'-O-glucuronide | |
0.0025 | - |
IC50: 0.002 mM with 2-hydroxyestradiol as substrate, IC50: 0.0025 mM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin-3-gallate-3''-O-glucuronide | |
0.004 | - |
IC50: 0.0025 mM with 2-hydroxyestradiol as substrate, IC50: 0.004 mM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin-3-gallate-4''-O-glucuronide | |
0.0085 | - |
IC50: 0.0085 mM with 2-hydroxyestradiol or 4-hydroxyestradiol as substrate | Homo sapiens | quercetin | |
0.04 | - |
IC50: 0.032 mM with 2-hydroxyestradiol as substrate, IC50: 0.04 mM with 4-hydroxyestradiol as substrate | Homo sapiens | 4'-O-methyl-(-)-epigallocatechin | |
0.044 | - |
IC50: 0.044 mM with 2-hydroxyestradiol as substrate, | Homo sapiens | (-)-epigallocatechin | |
0.05 | - |
IC50: 0.05 mM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)-epigallocatechin | |
0.08 | - |
IC50: 0.06 mM with 2-hydroxyestradiol as substrate, IC50: 0.08 mM with 4-hydroxyestradiol as substrate | Homo sapiens | (-)epicatechin |