Application | Comment | Organism |
---|---|---|
medicine | low COMT activity leads to increased pain sensitivity via a beta2/3-adrenergic mechanism. These findings are of considerable clinical importance, suggesting that pain conditions resulting from low COMT activity and/or elevated catecholamine levels can be treated with pharmacological agents that block both beta2- and beta3-adrenergic receptors | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
OR486 | depressed COMT activity results in enhanced mechanical and thermal pain sensitivity | Rattus norvegicus | |
Ro41-0960 | depressed COMT activity results in enhanced mechanical and thermal pain sensitivity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Synonyms | Comment | Organism |
---|---|---|
COMT | - |
Rattus norvegicus |