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Literature summary for 2.1.1.6 extracted from

  • Doyle, A.; Yager, J.
    Catechol-O-methyltransferase: Effects of the val108met polymorphism on protein turnover in human cells (2008), Biochim. Biophys. Acta, 1780, 27-33.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.6

Protein Variants

Protein Variants Comment Organism
V108M the mutation is associated with an increased risk for breast cancer Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform S-COMT Homo sapiens 5829
-
membrane isoform MB-COMT Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast epithelium
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-
ZR-75-1 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
MB-COMT membrane-bound enzyme form Homo sapiens
S-COMT soluble enzyme form Homo sapiens