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Literature summary for 2.1.1.6 extracted from

  • Huo, C.; Yang, H.; Cui, Q.C.; Dou, Q.P.; Chan, T.H.
    Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs (2010), Bioorg. Med. Chem., 18, 1252-1258.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.6

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin-3-O-gallate
-
 Homo sapiens
(2R,3R)-5,7-bis(acetyloxy)-2-[3,4,5-tris(acetyloxy)phenyl]-3,4-dihydro-2H-chromen-3-yl 3,4-bis(acetyloxy)-5-(2-oxopropyl)benzoate
-
 Homo sapiens
(2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis(3,4,5-trihydroxybenzoate)
-
 Homo sapiens
(2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis(3,5-dihydroxybenzoate)
-
 Homo sapiens
(2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis[3,4,5-tris(acetyloxy)benzoate]
-
 Homo sapiens
(2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis[3,5-bis(acetyloxy)benzoate]
-
 Homo sapiens
additional information (-)-epigallocatechin is not active even at a concentration of 0.05 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-epigallocatechin-3-O-gallate + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
COMT
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.029
-
 70-79% inhibition at 0.025-0.05 mM Homo sapiens (2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diyl bis(3,5-dihydroxybenzoate)