Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | MB-COMT | Mus musculus | 16020 | - |
soluble | S-COMT | Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
24000 | - |
short catechol-O-methyltransferase transcript of S-COMT in the liver, SDS-PAGE | Mus musculus |
28000 | - |
long catechol-O-methyltransferase transcript of MB-COMT in the liver, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
duodenum | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
additional information | sexual dimorphism and activity of the two COMT isoforms seems to be tissue specific and more prominent in peripheral tissues than in the brain | Mus musculus | - |
prefrontal cortex | - |
Mus musculus | - |
striatum | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa + S-adenosyl-L-methionine | - |
Mus musculus | S-adenosyl-L-homocysteine + 3-O-methyldopa | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MB-COMT | membrane-bound catechol-O-methyltransferase | Mus musculus |
S-COMT | soluble catechol-O-methyltransferase | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | lack of S-COMT does not affect the levels of L-DOPA in plasma or peripheral tissues, whereas in the full COMT-knock-out mice, these levels are increased. The total COMT activity in the S-COMT-deficient mice is 22-47% of that in the wild type mice. In S-COMT-deficient mice, MB-COMT in the liver and the duodenum is able to O-methylate about one-half of exogenous L-Dopa | Mus musculus |