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Literature summary for 2.1.1.6 extracted from

  • Kaeenmaeki, M.; Tammimaeki, A.; Garcia-Horsman, J.A.; Myoehaenen, T.; Schendzielorz, N.; Karayiorgou, M.; Gogos, J.A.; Maennistoe, P.T.
    Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice (2009), Br. J. Pharmacol., 158, 1884-1894.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane MB-COMT Mus musculus 16020
-
soluble S-COMT Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
short catechol-O-methyltransferase transcript of S-COMT in the liver, SDS-PAGE Mus musculus
28000
-
long catechol-O-methyltransferase transcript of MB-COMT in the liver, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
duodenum
-
Mus musculus
-
liver
-
Mus musculus
-
additional information sexual dimorphism and activity of the two COMT isoforms seems to be tissue specific and more prominent in peripheral tissues than in the brain Mus musculus
-
prefrontal cortex
-
Mus musculus
-
striatum
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa + S-adenosyl-L-methionine
-
Mus musculus S-adenosyl-L-homocysteine + 3-O-methyldopa
-
?

Synonyms

Synonyms Comment Organism
MB-COMT membrane-bound catechol-O-methyltransferase Mus musculus
S-COMT soluble catechol-O-methyltransferase Mus musculus

General Information

General Information Comment Organism
malfunction lack of S-COMT does not affect the levels of L-DOPA in plasma or peripheral tissues, whereas in the full COMT-knock-out mice, these levels are increased. The total COMT activity in the S-COMT-deficient mice is 22-47% of that in the wild type mice. In S-COMT-deficient mice, MB-COMT in the liver and the duodenum is able to O-methylate about one-half of exogenous L-Dopa Mus musculus