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Literature summary for 2.1.1.6 extracted from

  • Kurogi, K.; Alazizi, A.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Sugahara, T.; Liu, M.C.
    Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs (2012), Biochem. Pharmacol., 84, 1186-1195.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.6

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
epinephrine + S-adenosyl-L-methionine
-
 Homo sapiens metanephrine + S-adenosyl-L-homocysteine
-
 ?
isoetharine + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
isoproterenol + S-adenosyl-L-methionine
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 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?

General Information

General Information Comment Organism
physiological function inhibition of catechol O-methyltransferase by inhibitor tropolone results in a decrease of the total amount of sulfated metabolites of dopamine, epinephrine, isoproterenol, and isoetharine. The sequential methylation and sulfation of dopamine, epinephrine, isoproterenol, and isoetharine is mediated by, respectively, the COMT and the cytosolic sulfotransferase SULT1A3 Homo sapiens